SOFRADIM PRODUCTION

Prosthesis ( 1 ) comprising a patch ( 2 ) made of biocompatible material, said patch having a generally plane geometric shape that defines two opposite faces, a centre, a length and a width of said patch, characterized in that said patch is provided, on one ( 2 a ) of its faces, with a single marking means ( 3 ) designed to indicate both the centre (C) of the patch and also the longitudinal direction of said patch.

The present invention relates to an openwork prosthetic knit ( 1 ) made from a single piece based on at least a first yarn made of biocompatible polymer material that defines a first face ( 2 ) and a second face that are opposite one another and from a second biocompatible yarn that generates barbs ( 5 ) that protrude outwards from at least said first face, characterized in that said first face comprises at least one longitudinal strip ( 4 ) in the direction of the manufacture of said knit, over which it is provided with said barbs ( 5 ), and at least one longitudinal strip ( 3 ) in the direction of the manufacture of said knit, over which it is free of such barbs. It also relates to a process for manufacturing such a knit ( 1 ) and to a prosthesis comprising such a knit ( 1 ).

The present invention relates to a prosthetic knit based on at least a first yarn of biocompatible polymer material defining first and second opposite and openwork faces, and on at least a second biocompatible and heat-fusible monofilament yarn, forming barbs that protrude outwards from at least said first face and are obtained by melting loops generated by said second yarn, the chart followed for the knitting of said first and second yarns on a warp knitting machine having three guide bars B 1, B 2, B 3 being the following, according to the ISO 11676 standard:—Bar B 1: 1.0/0.1//—Bar B 2: 1.0/7.7/6.6/7.7//—Bar B 3: 2.1/5.5/3.4/0.0// said second yarn following the chart of bar B 3. The present invention also relates to a process for manufacturing such a knit.

The present invention relates to an openwork prosthetic knit ( 1 ) made from a single piece based on first yarns of biocompatible polymer materials that define a first face ( 2 ) and a second face that are opposite one another and on a second biocompatible yarn that generates barbs ( 3 ) that protrude outwards from at least said first face, characterized in that said first face comprises at least one zone in which it is provided with said barbs and at least one zone ( 5 ) in which it is free of such barbs. It also relates to a process for manufacturing such a knit ( 1 ) and to a prosthesis comprising such a knit ( 1 ).

The present invention relates to a prosthesis ( 1 ) for the repair of an inguinal hernia, which prosthesis ( 1 ) is intended to be implanted by a posterior or open laparoscopic route and comprises: an openworked textile ( 2 ) made of biocompatible material, comprising a first face ( 2 a ) intended to be placed facing the biological tissues of the inguinal region, and a second face ( 2 b ) arranged opposite said first face and intended to be placed facing the peritoneum, said first face being provided with fastening means that are able to fix said textile in said biological tissues of the inguinal region, characterized in that at least a part of said second face ( 2 b ) is covered with a non-porous coating ( 7 ) composed of a material that is hydrosoluble at 37° C. and non-hydrosoluble at 25° C. The invention also relates to a method for producing such a prosthesis.

The present disclosure relates to implantable medical devices having a non-bioabsorbable substrate and an amphiphilic coating covalently bonded to the substrate for reducing the inflammatory response to the device after implantation.

A medical device includes a substrate having at least a portion thereof functionalized with at least one reactive member and a chemotactic agent functionalized with at least one complementary reactive member. The at least one reactive member and the at least one complementary reactive member are covalently bonded, adhering the chemotactic agent to the substrate.

Implants include a porous layer made from a composition including a compound wherein collagen is cross-linked to a glycosaminoglycan, the porous layer being optionally joined to a collagen film.

A method for treating a wound or defect at a surgical target site using a minimally invasive surgical procedure is provided which includes utilizing a surgical access device such as a port or a catheter having a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having affinity for binding a cellular component of tissue cells located at the target site; contacting the surface of the access device with the tissue cells, wherein upon contact of the reactive members on the surface of the access device with the tissue cells, the reactive members are released from the surface of the access device and bind to the tissue; providing a tissue repair member having secured thereto a plurality of complementary reactive members of the specific binding pair; and applying the tissue repair member to the tissue, wherein upon contact of the complementary reactive members on the surface of the tissue repair member with the reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus bonding the tissue repair member to the tissue. A surgical access device for use in minimally invasive surgery is provided which includes a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having an affinity for binding a cellular component of tissue cells and another affinity for binding complementary members of the specific binding pair.

The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed in a hopper. The mixed precursors are then extruded through an extrusion die to crosslink and produce a filament. Polymerization of the first and second precursors is catalyzed by transition metal ions.