Targeted Small Molecule Therapeutics

Design and synthesis of acyclic or carbocyclic organic compounds that selectively modulate specific biological targets or pathways for the treatment of diseases.

28,767 US filings from 6,994 companies since 2023 · 2023: 7,350 · 2024: 9,375 · 2025: 8,545 · 2026 YTD: 3,497

Pharmaceutical PreparationsAcyclic / Carbocyclic CompoundsHeterocyclic Compounds (Pharma)

Top companies

Ranked by filings in this theme since 2023. 2026 is partial.

#	Company	Since 2023	2023	2024	2025	2026 YTD	YoY
1	KING FAISAL UNIVERSITY	439	18	382	38	1	-90.1%
2	Hoffmann-La Roche Inc.	315	88	98	83	46	-15.3%
3	The Regents of the University of California	313	92	101	74	46	-26.7%
4	Incyte Corporation	290	68	97	89	36	-8.2%
5	Novartis AG	282	68	98	88	28	-10.2%
6	Bristol-Myers Squibb Company	262	77	88	73	24	-17.0%
7	Gilead Sciences, Inc.	255	65	83	86	21	+3.6%
8	Dana-Farber Cancer Institute, Inc.	237	66	72	72	27	0.0%
9	Merck Sharp & Dohme LLC	222	43	74	76	29	+2.7%
10	Genentech, Inc.	207	56	59	75	17	+27.1%
11	Janssen Pharmaceutica NV	206	84	71	40	11	-43.7%
12	BAYER AKTIENGESELLSCHAFT	170	72	44	38	16	-13.6%
13	Boehringer Ingelheim International GmbH	170	39	70	51	10	-27.1%
14	AstraZeneca AB	152	43	57	39	13	-31.6%
15	AMGEN INC.	150	33	35	66	16	+88.6%
16	TAKEDA PHARMACEUTICAL COMPANY LIMITED	148	38	46	42	22	-8.7%
17	Pfizer Inc.	145	41	48	37	19	-22.9%
18	ELI LILLY AND COMPANY	143	42	42	40	19	-4.8%
19	Board of Regents, The University of Texas System	137	43	41	40	13	-2.4%
20	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE	124	35	28	39	22	+39.3%
21	Kymera Therapeutics, Inc.	116	36	26	34	20	+30.8%
22	Vanderbilt University	115	25	34	41	15	+20.6%
23	INTRA-CELLULAR THERAPIES, INC.	113	17	36	46	14	+27.8%
24	Vertex Pharmaceuticals Incorporated	108	36	23	36	13	+56.5%
25	Northwestern University	107	24	46	25	12	-45.7%