Nucleic Acid-Based Therapies

Therapeutic strategies employing nucleic acids (DNA, RNA, oligonucleotides) to modulate gene expression, deliver genetic material, or interfere with disease-causing pathways. Includes gene therapy using viral vectors.

16,760 US filings from 4,567 companies since 2023 · 2023: 4,258 · 2024: 5,206 · 2025: 5,220 · 2026 YTD: 2,076

Pharmaceutical PreparationsTherapeutic Activity (Pharma)

Top companies

Ranked by filings in this theme since 2023. 2026 is partial.

#	Company	Since 2023	2023	2024	2025	2026 YTD	YoY
1	The Regents of the University of California	348	110	106	92	40	-13.2%
2	UNIVERSITY OF MASSACHUSETTS	240	62	69	67	42	-2.9%
3	President and Fellows of Harvard College	229	64	61	76	28	+24.6%
4	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	227	54	68	77	28	+13.2%
5	Alnylam Pharmaceuticals, Inc.	225	54	80	69	22	-13.8%
6	ModernaTX, Inc.	192	52	60	60	20	0.0%
7	The Broad Institute, Inc.	185	41	48	73	23	+52.1%
8	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	162	52	46	44	20	-4.3%
9	Ionis Pharmaceuticals, Inc.	136	35	49	40	12	-18.4%
10	Wyvern Pharmaceuticals Inc.	127	·	2	83	42	+4050.0%
11	Gilead Sciences, Inc.	124	44	42	33	5	-21.4%
12	The Board of Trustees of the Leland Stanford Junior University	107	24	36	30	17	-16.7%
13	TRANSLATE BIO, INC.	104	27	32	31	14	-3.1%
14	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED	100	24	22	36	18	+63.6%
15	CureVac SE	99	24	31	32	12	+3.2%
16	Duke University	97	21	44	20	12	-54.5%
17	Hoffmann-La Roche Inc.	93	29	24	29	11	+20.8%
18	The Board of Regents of The University of Texas System	90	19	44	18	9	-59.1%
19	Regeneron Pharmaceuticals, Inc.	88	12	19	40	17	+110.5%
20	BioNTech SE	80	14	26	31	9	+19.2%
21	GlaxoSmithKline Biologicals SA	80	45	23	11	1	-52.2%
22	The Johns Hopkins University	79	25	19	24	11	+26.3%
23	Yale University	79	26	21	25	7	+19.0%
24	Flagship Pioneering Innovations VI, LLC	77	18	31	18	10	-41.9%
25	The General Hospital Corporation	76	24	29	16	7	-44.8%