Immunomodulatory Protein Design

Design and engineering of proteins or peptides to directly modulate immune responses, including enhancing antigen presentation, suppressing inflammation, or activating specific immune cell types.

17,789 US filings from 5,157 companies since 2023 · 2023: 5,131 · 2024: 5,508 · 2025: 5,104 · 2026 YTD: 2,046

Peptides & Proteins

Top companies

Ranked by filings in this theme since 2023. 2026 is partial.

#	Company	Since 2023	2023	2024	2025	2026 YTD	YoY
1	Regeneron Pharmaceuticals, Inc.	307	78	95	88	46	-7.4%
2	Immatics Biotechnologies GmbH	296	118	120	54	4	-55.0%
3	Bristol-Myers Squibb Company	228	74	74	55	25	-25.7%
4	The Regents of the University of California	228	72	70	57	29	-18.6%
5	Hoffmann-La Roche Inc.	186	45	59	52	30	-11.9%
6	Novartis AG	179	54	51	51	23	0.0%
7	The Board of Trustees of the Leland Stanford Junior University	172	51	53	49	19	-7.5%
8	JANSSEN BIOTECH, INC.	159	47	50	48	14	-4.0%
9	AMGEN INC.	131	31	41	40	19	-2.4%
10	Board of Regents, The University of Texas System	126	28	43	34	21	-20.9%
11	Genentech, Inc.	125	31	44	36	14	-18.2%
12	Chugai Seiyaku Kabushiki Kaisha	124	33	40	30	21	-25.0%
13	Xencor, Inc.	123	36	37	36	14	-2.7%
14	Merck Sharp & Dohme LLC	118	33	39	30	16	-23.1%
15	Wyvern Pharmaceuticals Inc.	115	1	3	76	35	+2433.3%
16	GlaxoSmithKline Biologicals SA	105	60	31	11	3	-64.5%
17	Pfizer Inc.	96	33	26	24	13	-7.7%
18	Cue Biopharma, Inc.	92	30	36	21	5	-41.7%
19	Sanofi	92	27	28	29	8	+3.6%
20	Dana-Farber Cancer Institute, Inc.	86	31	23	22	10	-4.3%
21	Gilead Sciences, Inc.	79	20	24	26	9	+8.3%
22	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	78	25	19	27	7	+42.1%
23	Boehringer Ingelheim International GmbH	77	27	27	17	6	-37.0%
24	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	77	18	24	25	10	+4.2%
25	Incyte Corporation	76	18	23	29	6	+26.1%